Argentine giant Independiente continue to struggle after falling to a 3-1 loss at home to Godoy Cruz in Group 8 of the Copa Libertadores.
The loss leaves Independiente in bottom place after the first meetings between all teams in the group.
The home side went into the break behind despite striker Facundo Parra opening the scoring in the 16th minute.
Midfielder Hernan Fredes turned the ball into his own net inside half an hour before winger Ariel Rojas gave the visitors the lead four minutes later.
Forward Ruben Ramirez clinched the the points for his side 11 minutes after half-time when he made it 3-1.
It moved Godoy Cruz into top spot in the tightly contested group after starting the day bottom.
Cerro Porteno maintained their unbeaten start in Group 5 but had to settle for a 1-1 draw with Deportivo Tachira.
Forward Roberto Nanni gave the Paraguayans a 28th-minute lead with his fourth goal of the tournament but they relinquished the advantage on the hour mark.
Columbian striker Sergio Herrera gave the Venezuelan outfit their equalizer, though they remain winless and bottom of the group after securing two draws.
Union Espanola moved off the bottom of Group 4 thanks to two goals in the opening half an hour in their 2-1 victory over Velez Sarsfield.
Martin Liguera opened the scoring for the Chilean outfit in the third minute in fortuitous fashion after a scramble fell for him to volley into the roof of the net from six yards.
Midfielder Braulio Leal headed home the second in the 26th minute thanks to his quick reactions after having his initial header saved.
The visitors pulled one back with 20 minutes to play courtesy of substitute David Ramirez, who placed his shot underneath goalkeeper Eduardo Lobos.
Union Espanola remain just outside the top two on goal difference while Velez Sarsfield are bottom.
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