Beaten 2010 quarter-finalists Libertad of Paraguay made a winning start to their Copa Libertadores campaign with a 2-1 win over San Luis.
Argentine Nicolas Pavlovich opened the scoring for visitors Libertad in the 18th minute at Estadio Alfonso Lastras Ramirez.
Mexican hosts San Luis equalised through Juan Manuel Cavallo five minutes before half-time, but midfielder Sergio Aquino restored the lead on 56 minutes.
San Luis finished with 10 men after Ignacio Torres received a second yellow card six minutes from time.
The win puts Libertad top of Group One, with Once Caldas and Universidad San Martin to meet on Wednesday.
Argentine club Velez Sarsfield made an impressive start with a 3-0 home win over Venezuela’s Caracas.
The visitors were a man short from the 12th minute after midfielder Angelo Puentes was sent off.
But it took Velez until just before half-time to take advantage, when Maximiliano Moralez broke the deadlock.
David Ospina Ramirez made it 2-0 on 59 minutes, before forward Juan Manuel Martinez completed the scoring from the penalty spot seven minutes from time.
Velez are the first team to put points on the board in Group Four ahead of Union Espanola’s meeting with Universidad Catolica on Wednesday.
Colombia’s Deportes Tolima opened with a 1-0 win at home to Paraguayan club Guarani.
Danny Otero scored the game’s only goal in the 83rd minute at the Estadio Manuel Murillo Toro.
Tolima top Group Seven ahead of the heavyweight clash between Cruzeiro and Estudiantes de La Plata on Wednesday.
Two-time competition winners Santos of Brazil were held 0-0 away to Venezuelan side Deportivo Tachira.
Mexican team America defeated Uruguayan visitors Nacional 2-0 at Estadio Azteca.
Vicente Sanchez had America in front after just three minutes before Vicente Vuoso doubled the lead in the 48th minute.
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