Premier League leaders Liverpool will face city rivals Everton in the fourth round of the English FA Cup after the Merseyside teams were the first two clubs selected in Sunday's draw.
The north-west giants met in the 1986 and 1989 FA Cup finals, Liverpool winning on both occasions.
Meanwhile Nottingham Forest's reward for knocking out Premier League Manchester City was a fourth round clash with East Midlands rivals Derby, who also play in the second-tier Championship.
Third-tier Hartlepool, conquerors of Stoke in the third round, will have the chance to inflict further Cup misery on a Premier League side when they welcome West Ham to the north-east.
Manchester United will be up against Premier League rivals Tottenham if they see off Southampton, in a repeat of the 1976 final, later Sunday.
Holders Portsmouth, who must first get past Bristol City after a goalless draw at Fratton Park, could face either non-league Histon or Swansea, whose third round clash was postponed because of a frozen pitch.
Cardiff, last season's losing finalists, are up against Arsenal in a repeat of the 1927 final which the Welsh club won to become the only non-English side to lift the FA Cup.
Cheltenham or Doncaster can now look forward to playing Aston Villa after the Premier League high-flyers won 2-1 away to Gillingham earlier Sunday.
Sunderland will have an all top-flight clash against Blackburn Rovers provided their Premier League rivals get past non-league Blyth Spartans in Monday's third round tie.
Non-league Kettering are at home to Premier League Fulham while Torquay, the other non-league team left in the draw, will be at home to 1987 Cup winners Coventry City.
Ties will be played on the weekend of January 24-25, with third round replays due to take place on January 13.
FA Cup 4th rd draw:
Liverpool v Everton
Southampton or Manchester United v Tottenham Hotspur
Hull or Newcastle v Millwall or Crewe
Sunderland v Blyth Spartans or Blackburn Rovers
Hartlepool v West Ham
Leyton Orient or Sheffield United v Charlton or Norwich
Cardiff v Arsenal
Portsmouth or Bristol City v Histon or Swansea
Chelsea or Southend v Ipswich
Cheltenham or Doncaster v Aston Villa
West Brom or Peterborough v QPR or Burnley
Torquay v Coventry
Kettering v Fulham
Watford v Leicester or Crystal Palace
Derby v Nottingham Forest
Birmingham or Wolverhampton v Middlesbrough
Ties to be played over the weekend of Jan 24-25
Third round replays Jan 13
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