Wolves went to the bottom of the table after suffering their fourth league defeat of the season at Molineux.
Wanderers never really looked like coming back from Hugo Rodallega and Tom Cleverley’s first-half strikes.
Steven Fletcher’s late goal was a mere consolation as Wigan moved three points clear of the relegation zone.
Sylvan Ebanks-Blake wasted a good opportunity for the home side in a bright opening spell, and things went from bad to worse for Wolves from then onwards.
After the home defence failed to clear Ben Watson’s corner in the 10th minute, Gary Caldwell fired into the path of Rodallega.
The Colombian striker still had a lot of work to do, which he did with aplomb, shrugging off two defenders before lashing past Wayne Hennessey to score.
Rodallega took advantage of slack Wolves defending when he set up Cleverley to make it 2-0 to the visitors 10 minutes later.
A pin-point pass picked out the Manchester United loan man, who finished neatly after powering forward.
Wolves felt they should have had a penalty on the half-hour mark when Stephen Ward was sent tumbling in the box, but it was denied.
Mick McCarthy’s men pulled one back when 6.5 million pounds signing Fletcher came off the bench to bundle home in the 87th minute.
A cross into the Wigan penalty area was not cleared and Fletcher kept a calm head when the ball fell at his feet.
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